An instrument is a variable that affects treatment, affects the outcome only through treatment, and is independent of unmeasured confounders. Random assignment to encouragement, distance to hospital, or eligibility rules can serve as instruments.
IV estimates the effect for compliers — units whose treatment status changes when the instrument changes — not necessarily for everyone.
When IV helps
Use IV when treatment is endogenous: people self-select into programs, doctors prescribe based on unmeasured prognosis, or compliance is partial. A valid instrument mimics partial randomization.
Validity is the hard part
- Relevance: the instrument must shift treatment enough.
- Exclusion: the instrument must not affect outcome except through treatment.
- Independence: the instrument must not share unobserved causes with the outcome.